Will Creatine Make You Smarter? A Scientific Analysis

Creatine and Cognitive Performance

Creatine’s role in enhancing cognitive function has been gaining attention. Studies indicate that creatine supplementation may support brain health and function by increasing brain creatine levels, which can influence cognitive processes.

1. Cognitive Benefits in Healthy Adults

Research suggests that creatine supplementation can have positive effects on cognitive performance, particularly in tasks requiring short-term memory and quick thinking. A study by McMorris et al. (2007) found that creatine supplementation improved memory and intelligence test scores in healthy adults, especially when performing tasks under mental fatigue. Another study by Rae et al. (2003) reported increased cognitive performance.

2. Effects on Depression and PTSD

Creatine’s potential benefits extend beyond cognitive enhancement to mental health conditions. A study by the National Institute of Mental Health (NIMH) reported that creatine supplementation could offer modest improvements in symptoms of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). In a case study involving a 52-year-old woman with PTSD, depression, and fibromyalgia, improvements were observed with 4 weeks of creatine monohydrate supplementation [120]. Similarly, a study involving patients resistant to psychotropic treatments showed modest improvements in sleep and PTSD symptomology with creatine supplementation [131]. (Forbes, S. 2022)

Creatine and Traumatic Brain Injury (TBI)

Creatine’s potential benefits for managing and protecting against traumatic brain injury (TBI) are of particular interest. Although the research is still limited, early findings suggest that creatine could play a protective role in brain injury management. (Fundaro, G. 2024)

1. Clinical Evidence

A pilot study with children and adolescents suffering from severe TBI found that creatine supplementation led to decreased hospital stay, improved neurophysical and cognitive outcomes, and reduced post-traumatic headaches and fatigue [143,144,145]. This study indicates that creatine might aid recovery from severe brain injuries. (Forbes, S. 2022)

2. Pre-Clinical Research

Pre-clinical studies have shown promising results. Research in mice and rats indicates that creatine supplementation before or after a TBI can reduce cortical damage, oxidative stress, and improve mitochondrial function [146,147]. These studies suggest that creatine could help protect against brain damage and support recovery following injury. (Forbes, S. 2022)

Future Directions

Creatine has shown promising potential for cognitive and neuroprotective benefits based on preliminary research. As ongoing studies continue to explore its long-term effects and optimal use, creatine is emerging as a potential supporter of cognitive function and overall brain health.

Conclusion

Creatine is widely recognized for its role in enhancing physical performance, but emerging research suggests it may also benefit brain health and cognitive function. From improving memory and mental fatigue resistance to offering potential support for mental health conditions and TBI recovery, creatine presents an intriguing option for enhancing brain health. 

References

1. Gabrielle Fundaro, Ph.D., CHC. (2024). How Using Creatine Can Benefit Your Brain. Retrieved from Barbend.

2. Forbes, S., et al. (2022). Effects of Creatine Supplementation on Brain Function and Health. Retrieved from MDPI.

3. McMorris, T., et al. (2007). Creatine supplementation and cognitive performance in elderly individuals. Retrieved from PubMed.

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